Rewild: South America focuses on the rich fauna and flora of the South American ecoregions Caatinga, Cerrado, Gran Chaco, Pantanal, Amazon rainforest and Atlantic rainforest. These regions and all their inhabitants exhibit diverse interrelationships and dependencies.

In the game, the players try to rewild an exploited, destroyed landscape, taking care of water, minerals and seeds for life to flourish again. Each biome allows different types of animals to thrive, and with each comes synergies and thus scoring opportunities. (contains all Kickstarter-exclusive components and Stretch Goals)